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Target
Glycogen phosphorylase, liver form
Ligand
BDBM50243643
Substrate
n/a
Meas. Tech.
ChEMBL_491654 (CHEMBL946372)
IC50
100000±n/a nM
Citation
 Evans, KA; Li, YH; Coppo, FT; Graybill, TL; Cichy-Knight, M; Patel, M; Gale, J; Li, H; Thrall, SH; Tew, D; Tavares, F; Thomson, SA; Weiel, JE; Boucheron, JA; Clancy, DC; Epperly, AH; Golden, PL Amino acid anthranilamide derivatives as a new class of glycogen phosphorylase inhibitors. Bioorg Med Chem Lett 18:4068-71 (2008) [PubMed]  Article 
Target
Name:
Glycogen phosphorylase, liver form
Synonyms:
Glycogen Phosphorylase (PYGL) | Glycogen Phosphorylase, liver form | Liver glycogen phosphorylase | PYGL | PYGL_HUMAN
Type:
Homodimer
Mol. Mass.:
97153.98
Organism:
Homo sapiens (Human)
Description:
Dimers associate into a tetramer to form the enzymatically active phosphorylase A.
Residue:
847
Sequence:
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDIEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLPWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFPKDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEAYVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNESNKVNGN
  
Inhibitor
Name:
BDBM50243643
Synonyms:
(S)-2-(2-(3-(2-chlorophenyl)ureido)-2-naphthamido)-2-cyclohexylacetic acid | CHEMBL471752
Type:
Small organic molecule
Emp. Form.:
C26H26ClN3O4
Mol. Mass.:
479.955
SMILES:
OC(=O)[C@@H](NC(=O)c1cc2ccccc2cc1NC(=O)Nc1ccccc1Cl)C1CCCCC1 |r|
Structure:
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