Target
Lysosomal alpha-mannosidase
Ligand
BDBM50263048
Substrate
n/a
Meas. Tech.
ChEMBL_489067 (CHEMBL987287)
IC50
350000±n/a nM
Citation
 Fiaux, HKuntz, DAHoffman, DJanzer, RCGerber-Lemaire, SRose, DRJuillerat-Jeanneret, L Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site. Bioorg Med Chem 16:7337-46 (2008) [PubMed]  Article 
Target
Name:
Lysosomal alpha-mannosidase
Synonyms:
LAMAN | MA2B1_HUMAN | MAN2B1 | MANB
Type:
PROTEIN
Mol. Mass.:
113753.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1432452
Residue:
1011
Sequence:
MGAYARASGVCARGCLDSAGPWTMSRALRPPLPPLCFFLLLLAAAGARAGGYETCPTVQPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWRASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQAKGSSVHVLYSTPACYLWELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLSNALARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFVVKDPNGRTVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRSWSPALTIENEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNTGPTPHQTPYQLDPANITLEPMEIRTFLASVQWKEVDG
  
Inhibitor
Name:
BDBM50263048
Synonyms:
(3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-phenylethylamino)methyl)pyrrolidin-2-one | (3R,4R,5R)-3,4-dihydroxy-5-({[(1R)-2-hydroxy-1-phenylethyl]amino}methyl)pyrrolidin-2-one | CHEMBL476925
Type:
Small organic molecule
Emp. Form.:
C13H18N2O4
Mol. Mass.:
266.293
SMILES:
OC[C@H](NC[C@H]1NC(=O)[C@H](O)[C@@H]1O)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: