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Target
Mitogen-activated protein kinase 14
Ligand
BDBM15458
Substrate
n/a
Meas. Tech.
ChEMBL_489078 (CHEMBL987298)
Ki
36±n/a nM
Citation
 Angell, RM; Angell, TD; Bamborough, P; Bamford, MJ; Chung, CW; Cockerill, SG; Flack, SS; Jones, KL; Laine, DI; Longstaff, T; Ludbrook, S; Pearson, R; Smith, KJ; Smee, PA; Somers, DO; Walker, AL Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. Bioorg Med Chem Lett 18:4433-7 (2008) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM15458
Synonyms:
4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]-2-methoxypyrimidine | 4-[4-(4-fluorophenyl)-1-piperidin-4-yl-1H-imidazol-5-yl]-2-methoxypyrimidine | CHEMBL95692 | SB-242235 | SB242235
Type:
Small organic molecule
Emp. Form.:
C19H20FN5O
Mol. Mass.:
353.3934
SMILES:
COc1nccc(n1)-c1c(ncn1C1CCNCC1)-c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: