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Target
Cyclin-dependent kinase 2
Ligand
BDBM50263026
Substrate
n/a
Meas. Tech.
ChEMBL_490603 (CHEMBL984724)
IC50
3±n/a nM
Citation
 Finlay, MR; Acton, DG; Andrews, DM; Barker, AJ; Dennis, M; Fisher, E; Graham, MA; Green, CP; Heaton, DW; Karoutchi, G; Loddick, SA; Morgentin, R; Roberts, A; Tucker, JA; Weir, HM Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode. Bioorg Med Chem Lett 18:4442-6 (2008) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50263026
Synonyms:
CHEMBL478407 | N-(4-fluorophenyl)-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-amine
Type:
Small organic molecule
Emp. Form.:
C17H18FN5
Mol. Mass.:
311.3567
SMILES:
CC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(F)cc2)n1
Structure:
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