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Target
Prostaglandin D2 receptor
Ligand
BDBM50244809
Substrate
n/a
Meas. Tech.
ChEMBL_512418 (CHEMBL980759)
IC50
8450±n/a nM
Citation
 Debenham, SD; Chan, A; Lau, FW; Liu, W; Wood, HB; Lemme, K; Colwell, L; Habulihaz, B; Akiyama, TE; Einstein, M; Doebber, TW; Sharma, N; Wang, CF; Wu, M; Berger, JP; Meinke, PT Highly functionalized 7-azaindoles as selective PPAR gamma modulators. Bioorg Med Chem Lett 18:4798-801 (2008) [PubMed]  Article 
Target
Name:
Prostaglandin D2 receptor
Synonyms:
PD2R_HUMAN | PTGDR | Prostaglandin D2 | Prostaglandin D2 receptor | Prostanoid DP receptor
Type:
Enzyme
Mol. Mass.:
40288.87
Organism:
Homo sapiens (Human)
Description:
Q13258
Residue:
359
Sequence:
MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
  
Inhibitor
Name:
BDBM50244809
Synonyms:
(2R)-2-[3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenoxy]propanoicAcid | (R)-2-(3-((3-(4-chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl)methyl)phenoxy)propanoic acid | CHEMBL461571
Type:
Small organic molecule
Emp. Form.:
C27H21ClF3NO5
Mol. Mass.:
531.908
SMILES:
C[C@@H](Oc1cccc(Cn2c(C)c(C(=O)c3ccc(Cl)cc3)c3ccc(OC(F)(F)F)cc23)c1)C(O)=O |r|
Structure:
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