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Target
B1 bradykinin receptor
Ligand
BDBM50229295
Substrate
n/a
Meas. Tech.
ChEMBL_492574 (CHEMBL952241)
Ki
0.5±n/a nM
Citation
 Kuduk, SD; Chang, RK; Dipardo, RM; Di Marco, CN; Murphy, KL; Ransom, RW; Reiss, DR; Tang, C; Prueksaritanont, T; Pettibone, DJ; Bock, MG Bradykinin B1 receptor antagonists: an alpha-hydroxy amide with an improved metabolism profile. Bioorg Med Chem Lett 18:5107-10 (2008) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50229295
Synonyms:
(R)-N-((R)-1-(5-(5-chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)-3-fluoropyridin-2-yl)ethyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide | CHEMBL402831
Type:
Small organic molecule
Emp. Form.:
C20H16ClF5N4O3
Mol. Mass.:
490.811
SMILES:
C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(cc1F)-c1cc(Cl)cc(F)c1-c1noc(C)n1 |r|
Structure:
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