Reaction Details Report a problem with these data
Target
B1 bradykinin receptor
Ligand
BDBM50264723
Substrate
n/a
Meas. Tech.
ChEMBL_492574 (CHEMBL952241)
Ki
1.000±n/a nM
Citation
Kuduk, SD; Chang, RK; Dipardo, RM; Di Marco, CN; Murphy, KL; Ransom, RW; Reiss, DR; Tang, C; Prueksaritanont, T; Pettibone, DJ; Bock, MG Bradykinin B1 receptor antagonists: an alpha-hydroxy amide with an improved metabolism profile. Bioorg Med Chem Lett 18:5107-10 (2008) [PubMed] Article
More Info.:
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
Inhibitor
Name:
BDBM50264723
Synonyms:
CHEMBL484882 | N-(1-(5-(5-chloro-3-fluoro-2-(2-methyl-2H-tetrazol-5-yl)phenyl)-3-fluoropyridin-2-yl)ethyl)-3,3-difluoro-1-hydroxycyclopentanecarboxamide
Type:
Small organic molecule
Emp. Form.:
C21H19ClF4N6O2
Mol. Mass.:
498.861
SMILES:
CC(NC(=O)C1(O)CCC(F)(F)C1)c1ncc(cc1F)-c1cc(Cl)cc(F)c1-c1nnn(C)n1