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TargetBradykinin B1 receptor
LigandBDBM50264836
Substrate/Competitorn/a
Meas. Tech.ChEMBL_492574
Ki 0.41±n/a nM
Citation Kuduk, SDChang, RKDipardo, RMDi Marco, CNMurphy, KLRansom, RWReiss, DRTang, CPrueksaritanont, TPettibone, DJBock, MG Bradykinin B1 receptor antagonists: an alpha-hydroxy amide with an improved metabolism profile. Bioorg Med Chem Lett18:5107-10 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bradykinin B1 receptor
Name:Bradykinin B1 receptor
Synonyms:B1 BRADYKININ | B1 bradykinin receptor | B1R | BK-1 receptor
Type:Enzyme
Mol. Mass.:40508.87
Organism:Homo sapiens (Human)
Description:P46663
Residue:353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50264836
NameBDBM50264836
Synonyms:(R)-N-(1-(5-(5-chloro-3-fluoro-2-(2-methyl-2H-tetrazol-5-yl)phenyl)-3-fluoropyridin-2-yl)ethyl)-4,4-difluoro-1-hydroxycyclohexanecarboxamide | CHEMBL484055
TypeSmall organic molecule
Emp. Form.C22H21ClF4N6O2
Mol. Mass.512.888
SMILESC[C@@H](NC(=O)C1(O)CCC(F)(F)CC1)c1ncc(cc1F)-c1cc(Cl)cc(F)c1-c1nnn(C)n1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a