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Target
D(3) dopamine receptor
Ligand
BDBM50253327
Substrate
n/a
Meas. Tech.
ChEMBL_539668 (CHEMBL1028976)
Ki
5.7±n/a nM
Citation
 Chen, J; Collins, GT; Zhang, J; Yang, CY; Levant, B; Woods, J; Wang, S Design, synthesis, and evaluation of potent and selective ligands for the dopamine 3 (D3) receptor with a novel in vivo behavioral profile. J Med Chem 51:5905-8 (2008) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50253327
Synonyms:
CHEMBL524005 | Naphthalene-2-carboxylic acid {4-[2-((R)-8-methoxy-1,2,4,4a,5,6-hexahydro-pyrazino[1,2-a]quinolin-3-yl)-ethyl]-cyclohexyl}-amide
Type:
Small organic molecule
Emp. Form.:
C32H39N3O2
Mol. Mass.:
497.671
SMILES:
COc1ccc2N3CCN(CC[C@H]4CC[C@@H](CC4)NC(=O)c4ccc5ccccc5c4)C[C@H]3CCc2c1 |r,wU:15.18,wD:12.11,32.35,(2.62,-19.96,;3.96,-19.2,;5.29,-20,;5.26,-21.55,;6.58,-22.33,;7.92,-21.59,;9.24,-22.37,;9.22,-23.92,;10.56,-24.7,;11.89,-23.93,;13.22,-24.72,;14.57,-23.95,;15.89,-24.73,;15.88,-26.28,;17.22,-27.06,;18.55,-26.29,;18.56,-24.75,;17.24,-23.97,;19.89,-27.06,;21.23,-26.3,;21.23,-24.75,;22.56,-27.07,;22.55,-28.61,;23.88,-29.39,;25.22,-28.62,;26.57,-29.39,;27.9,-28.62,;27.9,-27.06,;26.56,-26.3,;25.22,-27.07,;23.89,-26.3,;11.91,-22.4,;10.58,-21.63,;10.61,-20.09,;9.29,-19.3,;7.95,-20.05,;6.63,-19.26,)|
Structure:
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