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Target
Stromelysin-3
Ligand
BDBM50265077
Substrate
n/a
Meas. Tech.
ChEMBL_497413 (CHEMBL1002954)
Ki
0.230000±n/a nM
Citation
 Georgiadis, D; Yiotakis, A Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem 16:8781-94 (2008) [PubMed]  Article 
Target
Name:
Stromelysin-3
Synonyms:
MMP-11 | MMP11 | MMP11_HUMAN | Matrix metalloproteinase 11 | Matrix metalloproteinase-11 | SL-3 | ST3 | STMY3 | Stromelysin-3
Type:
PROTEIN
Mol. Mass.:
54592.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_850716
Residue:
488
Sequence:
MAPAAWLRSAAARALLPPMLLLLLQPPPLLARALPPDAHHLHAERRGPQPWHAALPSSPAPAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAEPANTFL
  
Inhibitor
Name:
BDBM50265077
Synonyms:
(S)-3-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-ylamino)-2-((2-methoxyphenylthio)methyl)-3-oxopropyl((R)-1-(benzyloxycarbonylamino)-2-phenylethyl)phosphinic acid | CHEMBL447457
Type:
Small organic molecule
Emp. Form.:
C38H41N4O7PS
Mol. Mass.:
728.794
SMILES:
COc1ccccc1SC[C@H](CP(O)(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |r|
Structure:
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