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Target
Disintegrin and metalloproteinase domain-containing protein 17
Ligand
BDBM50227856
Substrate
n/a
Meas. Tech.
ChEMBL_492682 (CHEMBL953112)
Ki
0.150000±n/a nM
Citation
 Georgiadis, D; Yiotakis, A Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem 16:8781-94 (2008) [PubMed]  Article 
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 17
Synonyms:
A disintegrin and metalloproteinase domain 17 | ADA17_PIG | ADAM 17 | ADAM17 | Snake venom-like protease | TACE | TNF-alpha-Converting Enzyme
Type:
Metalloprotease
Mol. Mass.:
12197.99
Organism:
Sus scrofa (pig)
Description:
Partially purified TACE was obtained from porcine spleen.
Residue:
112
Sequence:
MLREQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPIGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNE
  
Inhibitor
Name:
BDBM50227856
Synonyms:
(3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)methoxy)benzamido)-tetrahydro-2H-pyran-3-carboxamide | (3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)methoxy)benzamido)tetrahydro-2H-pyran-3-carboxamide | CHEMBL252893
Type:
Small organic molecule
Emp. Form.:
C24H25N3O5
Mol. Mass.:
435.4724
SMILES:
Cc1cc(COc2ccc(cc2)C(=O)N[C@@H]2CCOC[C@@H]2C(=O)NO)c2ccccc2n1 |r|
Structure:
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