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Target
Inosine-5'-monophosphate dehydrogenase 1
Ligand
BDBM50275685
Substrate
n/a
Meas. Tech.
ChEMBL_496847 (CHEMBL998516)
Ki
10300±n/a nM
Citation
 Chen, L; Wilson, DJ; Labello, NP; Jayaram, HN; Pankiewicz, KW Mycophenolic acid analogs with a modified metabolic profile. Bioorg Med Chem 16:9340-5 (2008) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase 1
Synonyms:
IMDH1_HUMAN | IMP dehydrogenase 1 | IMPD 1 | IMPD1 | IMPDH-I | IMPDH1 | Inosine Monophosphate Dehydrogenase Type 1 (IMPDH1) | Inosine-5'-monophosphate dehydrogenase (IMPDH)
Type:
Enzyme
Mol. Mass.:
55407.70
Organism:
Homo sapiens (Human)
Description:
Recombinant IMPDH1 expressed in E. coli.
Residue:
514
Sequence:
MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMEKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY
  
Inhibitor
Name:
BDBM50275685
Synonyms:
(E)-6-(2,4-dimethoxy-5-(oxazol-5-yl)phenyl)-4-methylhex-4-enoic acid | 6-(2,4-dimethoxy-5-(oxazol-5-yl)phenyl)-4-methylhex-4-enoic acid | CHEMBL443417
Type:
Small organic molecule
Emp. Form.:
C18H21NO5
Mol. Mass.:
331.363
SMILES:
COc1cc(OC)c(cc1C\C=C(/C)CCC(O)=O)-c1cnco1
Structure:
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