Target
Sodium-dependent noradrenaline transporter
Ligand
BDBM50274954
Substrate
n/a
Meas. Tech.
ChEMBL_493416 (CHEMBL944373)
Ki
9±n/a nM
Citation
 Bannwart, LMCarter, DSCai, HYChoy, JCGreenhouse, RJaime-Figueroa, SIyer, PSLin, CJLee, EKLucas, MCLynch, SMMadera, AMMoore, AOzboya, KRaptova, LRoetz, RSchoenfeld, RCStein, KASteiner, SVilla, MWeikert, RJZhai, Y Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. Bioorg Med Chem Lett 18:6062-6 (2008) [PubMed]  Article 
Target
Name:
Sodium-dependent noradrenaline transporter
Synonyms:
Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:
Multi-pass membrane protein
Mol. Mass.:
69337.72
Organism:
Homo sapiens (Human)
Description:
P23975
Residue:
617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
  
Inhibitor
Name:
BDBM50274954
Synonyms:
5-(3-benzylpyrrolidin-3-yl)-1H-indole-2-carboxamide | CHEMBL457931
Type:
Small organic molecule
Emp. Form.:
C20H21N3O
Mol. Mass.:
319.4002
SMILES:
NC(=O)c1cc2cc(ccc2[nH]1)C1(Cc2ccccc2)CCNC1
Structure:
Search PDB for entries with ligand similarity: