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Target
Adenosine receptor A3
Ligand
BDBM50254652
Substrate
n/a
Meas. Tech.
ChEMBL_559910 (CHEMBL1011021)
Ki
52±n/a nM
Citation
 Colotta, V; Capelli, F; Lenzi, O; Catarzi, D; Varano, F; Poli, D; Vincenzi, F; Varani, K; Borea, PA; Dal Ben, D; Volpini, R; Cristalli, G; Filacchioni, G Novel potent and highly selective human A(3) adenosine receptor antagonists belonging to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series: molecular docking analysis and pharmacological studies. Bioorg Med Chem 17:401-10 (2008) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50254652
Synonyms:
CHEMBL464041 | N-(2-(3-(trifluoromethyl)phenyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)benzamide
Type:
Small organic molecule
Emp. Form.:
C24H15F3N4O
Mol. Mass.:
432.3973
SMILES:
FC(F)(F)c1cccc(c1)-n1cc2c(n1)c(NC(=O)c1ccccc1)nc1ccccc21
Structure:
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