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Target
Vasopressin V2 receptor
Ligand
BDBM50246923
Substrate
n/a
Meas. Tech.
ChEMBL_560999 (CHEMBL1015239)
EC50
40±n/a nM
Citation
 Yea, CM; Allan, CE; Ashworth, DM; Barnett, J; Baxter, AJ; Broadbridge, JD; Franklin, RJ; Hampton, SL; Hudson, P; Horton, JA; Jenkins, PD; Penson, AM; Pitt, GR; Rivière, P; Robson, PA; Rooker, DP; Semple, G; Sheppard, A; Haigh, RM; Roe, MB New benzylureas as a novel series of potent, nonpeptidic vasopressin V2 receptor agonists. J Med Chem 51:8124-34 (2008) [PubMed]  Article 
Target
Name:
Vasopressin V2 receptor
Synonyms:
ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
40295.28
Organism:
Homo sapiens (Human)
Description:
P30518
Residue:
371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
  
Inhibitor
Name:
BDBM50246923
Synonyms:
1-(2-Chloro-4-[3-(2,6-difluorophenyl)ureidomethyl]benzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine | CHEMBL509960
Type:
Small organic molecule
Emp. Form.:
C25H22ClF2N3O2
Mol. Mass.:
469.911
SMILES:
Fc1cccc(F)c1NC(=O)NCc1ccc(C(=O)N2CCCCc3ccccc23)c(Cl)c1
Structure:
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