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Target
D(2) dopamine receptor
Ligand
BDBM50265390
Substrate
n/a
Meas. Tech.
ChEMBL_558361 (CHEMBL954163)
Ki
63±n/a nM
Citation
 Butini, S; Gemma, S; Campiani, G; Franceschini, S; Trotta, F; Borriello, M; Ceres, N; Ros, S; Coccone, SS; Bernetti, M; De Angelis, M; Brindisi, M; Nacci, V; Fiorini, I; Novellino, E; Cagnotto, A; Mennini, T; Sandager-Nielsen, K; Andreasen, JT; Scheel-Kruger, J; Mikkelsen, JD; Fattorusso, C Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior. J Med Chem 52:151-69 (2009) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50265390
Synonyms:
7-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyloxy]quinoline | CHEMBL497988
Type:
Small organic molecule
Emp. Form.:
C23H25Cl2N3O
Mol. Mass.:
430.37
SMILES:
Clc1cccc(N2CCN(CCCCOc3ccc4cccnc4c3)CC2)c1Cl
Structure:
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