Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50265445
Substrate
n/a
Meas. Tech.
ChEMBL_558363 (CHEMBL954165)
Ki
18±n/a nM
Citation
 Butini, SGemma, SCampiani, GFranceschini, STrotta, FBorriello, MCeres, NRos, SCoccone, SSBernetti, MDe Angelis, MBrindisi, MNacci, VFiorini, INovellino, ECagnotto, AMennini, TSandager-Nielsen, KAndreasen, JTScheel-Kruger, JMikkelsen, JDFattorusso, C Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior. J Med Chem 52:151-69 (2009) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50265445
Synonyms:
3-[5-[4-(2,3-Dichlorophenyl)piperazin-1-yl]pentyloxy]isoquinoline | CHEMBL495572
Type:
Small organic molecule
Emp. Form.:
C24H27Cl2N3O
Mol. Mass.:
444.397
SMILES:
Clc1cccc(N2CCN(CCCCCOc3cc4ccccc4cn3)CC2)c1Cl
Structure:
Search PDB for entries with ligand similarity: