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Target
TGF-beta receptor type-1
Ligand
BDBM50255960
Substrate
n/a
Meas. Tech.
ChEMBL_516221 (CHEMBL985078)
EC50
22000±n/a nM
Citation
 Bonafoux, D; Chuaqui, C; Boriack-Sjodin, PA; Fitch, C; Hankins, G; Josiah, S; Black, C; Hetu, G; Ling, L; Lee, WC 2-Aminoimidazoles inhibitors of TGF-beta receptor 1. Bioorg Med Chem Lett 19:912-6 (2009) [PubMed]  Article 
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Homo sapiens (Human)
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM50255960
Synonyms:
4-(6-methylpyridin-2-yl)-5-(quinoxalin-6-yl)thiazol-2-amine | CHEMBL519948
Type:
Small organic molecule
Emp. Form.:
C17H13N5S
Mol. Mass.:
319.384
SMILES:
Cc1cccc(n1)-c1nc(N)sc1-c1ccc2nccnc2c1
Structure:
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