Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50256972
Substrate
n/a
Meas. Tech.
ChEMBL_562705 (CHEMBL1012740)
Ki
3.1±n/a nM
Citation
 Colotta, V; Lenzi, O; Catarzi, D; Varano, F; Filacchioni, G; Martini, C; Trincavelli, L; Ciampi, O; Pugliese, AM; Traini, C; Pedata, F; Morizzo, E; Moro, S Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies. J Med Chem 52:2407-19 (2009) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_BOVIN | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | ADORA1 | Adenosine A1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36602.99
Organism:
BOVINE
Description:
ADENOSINE 0 BOVINE::P28190
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPRTYFHTCLKVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTPRRAVVAITGCWILSFVVGLTPMFGWNNLSAVERDWLANGSVGEPVIECQFEKVISMEYMVYFNFFVWVLPPLLLMVLIYMEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHMPRILIYIAIFLSHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPVDEDAPAERPDD
  
Inhibitor
Name:
BDBM50256972
Synonyms:
4-amino-2-phenylpyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-1(2H)-one | CHEMBL474636
Type:
Small organic molecule
Emp. Form.:
C14H10N6O
Mol. Mass.:
278.2688
SMILES:
Nc1nc2ncccc2n2c1nn(-c1ccccc1)c2=O
Structure:
Search PDB for entries with ligand similarity: