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Target
Muscarinic acetylcholine receptor M3
Ligand
BDBM50267471
Substrate
n/a
Meas. Tech.
ChEMBL_562970 (CHEMBL1015369)
IC50
122000±n/a nM
Citation
 Lainé, DI; McCleland, B; Thomas, S; Neipp, C; Underwood, B; Dufour, J; Widdowson, KL; Palovich, MR; Blaney, FE; Foley, JJ; Webb, EF; Luttmann, MA; Burman, M; Belmonte, K; Salmon, M Discovery of novel 1-azoniabicyclo[2.2.2]octane muscarinic acetylcholine receptor antagonists. J Med Chem 52:2493-505 (2009) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:
Enzyme
Mol. Mass.:
66151.03
Organism:
Homo sapiens (Human)
Description:
P20309
Residue:
590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
  
Inhibitor
Name:
BDBM50267471
Synonyms:
3-(2-Hydroxy-2,2-diphenylethyl)-1-(2-phenylethyl)-1-azoniabicyclo[2.2.2]octane Bromide | CHEMBL478069
Type:
Small organic molecule
Emp. Form.:
C29H34NO
Mol. Mass.:
412.5858
SMILES:
OC(CC1C[N+]2(CCc3ccccc3)CCC1CC2)(c1ccccc1)c1ccccc1 |(27.38,-21.98,;28.16,-23.31,;26.82,-24.08,;25.49,-23.31,;25.49,-21.76,;24.14,-20.98,;24.12,-19.44,;25.45,-18.65,;25.44,-17.11,;26.77,-16.33,;26.75,-14.79,;25.41,-14.03,;24.07,-14.82,;24.1,-16.36,;22.8,-21.76,;22.8,-23.31,;24.14,-24.08,;24.79,-22.79,;23.51,-22.15,;29.48,-22.53,;30.82,-23.29,;32.14,-22.51,;32.13,-20.97,;30.78,-20.21,;29.46,-21,;28.92,-24.64,;28.14,-25.96,;28.9,-27.28,;30.43,-27.29,;31.19,-25.96,;30.43,-24.64,)|
Structure:
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