Reaction Details Report a problem with these data
Target
Beta-3 adrenergic receptor
Ligand
BDBM50277503
Substrate
n/a
Meas. Tech.
ChEMBL_497812 (CHEMBL1007108)
EC50
0.830000±n/a nM
Citation
Hattori, K; Toda, S; Imanishi, M; Itou, S; Nakajima, Y; Washizuka, K; Araki, T; Hamashima, H; Tomishima, Y; Sakurai, M; Matsui, S; Imamura, E; Ueshima, K; Yamamoto, T; Yamamoto, N; Ishikawa, H; Nakano, K; Unami, N; Hamada, K; Matsumura, Y; Takamura, F Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5. J Med Chem 52:3063-72 (2009) [PubMed] Article
More Info.:
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3_CANLF | B3AR
Type:
PROTEIN
Mol. Mass.:
43072.49
Organism:
Canis familiaris
Description:
ChEMBL_497812
Residue:
405
Sequence:
MAPWPHGNGSVASWPAAPTPTPDAANTSGLPGAPWAVALAGALLALEVLATVGGNLLVIVAIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGRWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRRARAAVVLVWVVSAAVSFAPIMSKWWRVGADAEAQRCHSNPHCCAFASNIPYALLSSSVSFYLPLLVMLFVYARVFLVATRQLRLLRRELGRFPPAESPPAASRSRSPGPARRCASPAAVPSDRLRPARLLPLREHRALRTLGLIVGTFTLCWLPFFVANVMRALGGPSLVPSPALLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCRREEHRAAASPPGDPSAAPAALTSPAESSRCQALDGASWGIS
Inhibitor
Name:
BDBM50277503
Synonyms:
3-(Cyclohexyloxy)-4'-(2-{[(2R)-2-hydroxy-2-phenylethyl]amino}-ethyl)-N-(methylsulfonyl)biphenyl-4-carboxamide hydrochloride | CHEMBL469395
Type:
Small organic molecule
Emp. Form.:
C30H36N2O5S
Mol. Mass.:
536.682
SMILES:
CS(=O)(=O)NC(=O)c1ccc(cc1OC1CCCCC1)-c1ccc(CCNC[C@H](O)c2ccccc2)cc1 |r|