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Target
Beta-2 adrenergic receptor
Ligand
BDBM50236160
Substrate
n/a
Meas. Tech.
ChEMBL_497790 (CHEMBL1007086)
EC50
586±n/a nM
Citation
 Hattori, K; Toda, S; Imanishi, M; Itou, S; Nakajima, Y; Washizuka, K; Araki, T; Hamashima, H; Tomishima, Y; Sakurai, M; Matsui, S; Imamura, E; Ueshima, K; Yamamoto, T; Yamamoto, N; Ishikawa, H; Nakano, K; Unami, N; Hamada, K; Matsumura, Y; Takamura, F Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5. J Med Chem 52:3063-72 (2009) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM50236160
Synonyms:
(R)-4'-(2-(2-hydroxy-2-phenylethylamino)ethyl)-3-(isopropylamino)biphenyl-4-carboxylic acid | 4-(2-{[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)-3-(isopropylamino)-4-biphenylcarboxylic acid | CHEMBL270964
Type:
Small organic molecule
Emp. Form.:
C26H30N2O3
Mol. Mass.:
418.528
SMILES:
CC(C)Nc1cc(ccc1C(O)=O)-c1ccc(CCNC[C@H](O)c2ccccc2)cc1 |r|
Structure:
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