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Target
Adenosylhomocysteinase
Ligand
BDBM50280298
Substrate
n/a
Meas. Tech.
ChEBML_197371
Ki
112±n/a nM
Citation
 Liu, S; Wolfe, MS; Yuan, C; Ali, SM; Borchardt, RT Synthesis and evaluation of 4′-5′-dehydro-5′-fluoroaristeromycins as S-adenosyl-L-homocysteine (AdoHcy) hydrolase inhibitors Bioorg Med Chem Lett 2:1741-1744 (1992)    Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
Adenosylhomocysteinase | Ahcy | SAHH_RAT
Type:
PROTEIN
Mol. Mass.:
47537.52
Organism:
Rattus norvegicus
Description:
ChEMBL_1507790
Residue:
432
Sequence:
MADKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY
  
Inhibitor
Name:
BDBM50280298
Synonyms:
(1R,2S,3R)-3-(6-Amino-purin-9-yl)-5-[1-fluoro-meth-(Z)-ylidene]-cyclopentane-1,2-diol | CHEMBL49204
Type:
Small organic molecule
Emp. Form.:
C11H12FN5O2
Mol. Mass.:
265.2437
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1C\C(=C\F)[C@@H](O)[C@H]1O
Structure:
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