Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM50281039
Substrate
n/a
Meas. Tech.
ChEBML_63804
IC50
5000±n/a nM
Citation
Thompson, KR; Finke, PE; Shah, SK; Ashe, BM; Dahlgren, ME; Maycock, AL; Doherty, JB Inhibition of human leukocyte elastase. 6. Inhibition by 6-substituted penicillin esters. Bioorg Med Chem Lett 3:2283-2288 (1993) Article
More Info.:
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
Inhibitor
Name:
BDBM50281039
Synonyms:
(2S,5S,6S)-6-Acetoxy-3,3-dimethyl-4,7-dioxo-4lambda*4*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester | CHEMBL307225
Type:
Small organic molecule
Emp. Form.:
C17H19NO6S
Mol. Mass.:
365.401
SMILES:
CC(=O)O[C@@H]1[C@H]2N([C@@H](C(=O)OCc3ccccc3)C(C)(C)S2=O)C1=O