Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50281500
Substrate
n/a
Meas. Tech.
ChEBML_201269
Ki
1.04±n/a nM
Citation
 Wustrow, DJ; Wise, LD; Pugsley, TA; Meltzer, LT; Heffner, TG 4-Aryltetrahydropyridines as selective σ ligands Bioorg Med Chem Lett 3:277-280 (1993)    Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50281500
Synonyms:
4-{4-[4-(4-Chloro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-butyl}-pyridine | CHEMBL93442
Type:
Small organic molecule
Emp. Form.:
C20H23ClN2
Mol. Mass.:
326.863
SMILES:
Clc1ccc(cc1)C1=CCN(CCCCc2ccncc2)CC1 |t:8|
Structure:
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