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Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50016504
Substrate
n/a
Meas. Tech.
ChEMBL_48092 (CHEMBL662289)
Ki
0.150000±n/a nM
Citation
 Roques, BP; Corringer, PJ; Derrien, M; Daugé, V; Durieux, C Structure-based design and pharmacological properties of potent selective and systemically active CCK-B peptidomimetics Bioorg Med Chem Lett 3:847-850 (1993)    Article 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48445.79
Organism:
Homo sapiens (Human)
Description:
Stable expression of human CCK-2 receptors in HEK 293 cells.
Residue:
447
Sequence:
MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50016504
Synonyms:
(S)-3-(2-{[(S)-2-(2-{2-[2-tert-Butoxycarbonylamino-3-((S)-4-sulfooxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-(1H-indol-3-yl)-propionyl]-methyl-amino}-hexanoylamino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid | BC-264 | Boc-Asp-Tyr(SO3Na)-Nle-Gly-Trp-Nle-Asp-Phe-NH2 | Boc-Tyr(SO3Na)-gNle-mGIy-Trp-(N-Me)Nle-Asp-Phe-NH2 | CHEMBL428666
Type:
Small organic molecule
Emp. Form.:
C52H68N9O15S
Mol. Mass.:
1091.213
SMILES:
CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS([O-])(=O)=O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Structure:
Search PDB for entries with ligand similarity: