Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM50280907
Substrate
n/a
Meas. Tech.
ChEMBL_35431 (CHEMBL643791)
IC50
0.89±n/a nM
Citation
Klutchko, S; Hamby, JM; Hodges, JC Tetrahydroisoquinoline derivatives with AT2-specific angiotensin II reception binding inhibitory activity Bioorg Med Chem Lett 4:57-62 (1994) Article
More Info.:
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
Inhibitor
Name:
BDBM50280907
Synonyms:
(S)-1,4-Bis-diphenylcarbamoyl-piperazine-2-carboxylic acid | 1,4-di(diphenylcarbamoyl)-(2S)-hexahydro-2-pyrazinecarboxylic acid | CHEMBL290829 | L-159686
Type:
Small organic molecule
Emp. Form.:
C31H28N4O4
Mol. Mass.:
520.5784
SMILES:
OC(=O)[C@@H]1CN(CCN1C(=O)N(c1ccccc1)c1ccccc1)C(=O)N(c1ccccc1)c1ccccc1