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Target
Type-2 angiotensin II receptor
Ligand
BDBM50282401
Substrate
n/a
Meas. Tech.
ChEMBL_35431 (CHEMBL643791)
IC50
0.58±n/a nM
Citation
 Klutchko, S; Hamby, JM; Hodges, JC Tetrahydroisoquinoline derivatives with AT2-specific angiotensin II reception binding inhibitory activity Bioorg Med Chem Lett 4:57-62 (1994)    Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50282401
Synonyms:
CHEMBL157510 | PD-126055 | Potassium; (S)-5-benzyloxy-2-diphenylacetyl-6-methoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C32H28NO5
Mol. Mass.:
506.569
SMILES:
COc1ccc2CN([C@@H](Cc2c1OCc1ccccc1)C([O-])=O)C(=O)C(c1ccccc1)c1ccccc1
Structure:
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