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Target
Stromelysin-1
Ligand
BDBM50282552
Substrate
n/a
Meas. Tech.
ChEMBL_205642 (CHEMBL813250)
Ki
42±n/a nM
Citation
 Goulet, JL; Kinneary, JF; Durette, PL; Stein, RL; Harrison, RK; Izquierdo-Martin, M; Kuo, DW; Lin, TY; Hagmann, WK Inhibition of stromelysin-1 (MMP-3) by peptidyl phosphinic acids Bioorg Med Chem Lett 4:1221-1224 (1994)    Article 
Target
Name:
Stromelysin-1
Synonyms:
MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1
Type:
Enzyme
Mol. Mass.:
53973.13
Organism:
Homo sapiens (Human)
Description:
P08254
Residue:
477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
  
Inhibitor
Name:
BDBM50282552
Synonyms:
((R)-1-{(S)-2-[2-((S)-Acetylamino)-propionylamino]-propionylamino}-ethyl)-[2-((S)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-4-phenyl-butyl]-phosphinic acid | CHEMBL278334
Type:
Small organic molecule
Emp. Form.:
C33H48N5O7P
Mol. Mass.:
657.7373
SMILES:
CC(C)C[C@H](NC(=O)C(CCc1ccccc1)CP(O)(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(C)=O)C(=O)Nc1ccccc1
Structure:
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