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Target
Renin
Ligand
BDBM50282600
Substrate
n/a
Meas. Tech.
ChEMBL_195791 (CHEMBL801712)
IC50
41±n/a nM
Citation
 Smith, SA; Al-Barazanji, KA; Buckingham, RE; Cassidy, F; Coldwell, MC; Finney, FJ; Hadley, MS; Ham, P; Lawrence, SA; Nash, DJ; Tingley, EJ; Watson, JM The identification of a novel renin inhibitor of equivalent efficacy following oral or intravenous administration. Bioorg Med Chem Lett 4:1291-1296 (1994)    Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50282600
Synonyms:
(3S,4S)-5-Cyclohexyl-4-((S)-2-{(S)-2-[2-(1,1-dioxo-2,3-dihydro-1H-1lambda*6*-benzo[b]thiophen-3-yl)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoylamino)-3-hydroxy-pentanoic acid (2-imidazol-1-yl-ethyl)-amide | CHEMBL23071
Type:
Small organic molecule
Emp. Form.:
C41H56N6O7S
Mol. Mass.:
776.984
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC1CS(=O)(=O)c2ccccc12)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)CC(=O)NCCn1ccnc1
Structure:
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