Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50282605
Substrate
n/a
Meas. Tech.
ChEMBL_195791 (CHEMBL801712)
IC50
4±n/a nM
Citation
Smith, SA; Al-Barazanji, KA; Buckingham, RE; Cassidy, F; Coldwell, MC; Finney, FJ; Hadley, MS; Ham, P; Lawrence, SA; Nash, DJ; Tingley, EJ; Watson, JM The identification of a novel renin inhibitor of equivalent efficacy following oral or intravenous administration. Bioorg Med Chem Lett 4:1291-1296 (1994) Article
More Info.:
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Inhibitor
Name:
BDBM50282605
Synonyms:
(3S,4S)-5-Cyclohexyl-3-hydroxy-4-((S)-4-methyl-2-{(S)-2-[3-(3-oxo-2,3-dihydro-pyrido[4,3-b][1,4]thiazin-4-yl)-propionylamino]-3-phenyl-propionylamino}-pentanoylamino)-pentanoic acid (3-imidazol-1-yl-propyl)-amide | CHEMBL26510
Type:
Small organic molecule
Emp. Form.:
C42H58N8O6S
Mol. Mass.:
803.025
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN1C(=O)CSc2ccncc12)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)CC(=O)NCCCn1ccnc1