Target
Thromboxane-A synthase
Ligand
BDBM50283051
Substrate
n/a
Meas. Tech.
ChEMBL_210280 (CHEMBL808527)
IC50
4.30±n/a nM
Citation
 Vlattas, IDellureficio, JCohen, DSLee, WClarke, FDotson, RMathis, JZoganas, H Oxa-prostanoid analogs. Identification of an orally effective, dual thromboxane receptor antagonist /thromboxane synthase inhibitor Bioorg Med Chem Lett 4:2073-2076 (1994)    Article 
Target
Name:
Thromboxane-A synthase
Synonyms:
CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase
Type:
Enzyme
Mol. Mass.:
60524.67
Organism:
Homo sapiens (Human)
Description:
P24557
Residue:
533
Sequence:
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
  
Inhibitor
Name:
BDBM50283051
Synonyms:
(Z)-7-[(2S,3R,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyridin-3-yl-tetrahydro-furan-3-yl]-hept-4-enoic acid | CHEMBL63040
Type:
Small organic molecule
Emp. Form.:
C29H31NO4
Mol. Mass.:
457.5607
SMILES:
OC(=O)CC\C=C/CC[C@H]1[C@H](CO[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: