Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50284967
Substrate
n/a
Meas. Tech.
ChEBML_28195
IC50
11±n/a nM
Citation
 Kumazawa, THarakawa, HFukui, HShirakura, SOhishi, EYamada, K N-(1-phenyl-2-benzimidazolyl)-N′-phenylurea derivatives as potent in hibitors of acylcoa:cholesterol acyltransferase (ACAT) Bioorg Med Chem Lett 5:1829-1832 (1995)    Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50284967
Synonyms:
1-[1-(2,6-Dichloro-phenyl)-1H-benzoimidazol-2-yl]-3-(2,6-diisopropyl-phenyl)-urea | CHEMBL53287
Type:
Small organic molecule
Emp. Form.:
C26H26Cl2N4O
Mol. Mass.:
481.417
SMILES:
CC(C)c1cccc(C(C)C)c1NC(=O)Nc1nc2ccccc2n1-c1c(Cl)cccc1Cl |(13.12,-3.34,;13.91,-4.67,;12.42,-5.07,;15.45,-4.67,;16.2,-3.32,;17.76,-3.31,;18.53,-4.64,;17.76,-5.98,;18.53,-7.31,;17.78,-8.64,;20.07,-7.3,;16.22,-5.98,;15.47,-7.33,;13.93,-7.33,;13.14,-6,;13.17,-8.66,;11.63,-8.68,;10.71,-7.43,;9.25,-7.92,;7.91,-7.15,;6.58,-7.93,;6.58,-9.47,;7.91,-10.24,;9.25,-9.46,;10.72,-9.92,;10.72,-11.46,;9.36,-12.23,;8.05,-11.44,;9.36,-13.75,;10.69,-14.54,;12.02,-13.77,;12.02,-12.23,;13.37,-11.46,)|
Structure:
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