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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50051884
Substrate
n/a
Meas. Tech.
ChEMBL_28176 (CHEMBL638582)
IC50
370±n/a nM
Citation
 Smith, C; Ashton, MJ; Bush, RC; Facchini, V; Harris, NV; Hart, TW; Jordan, R; MacKenzie, R; Riddell, D RP 73163: A bioavailable alkylsulphinyl-diphenylimidazole ACAT inhibitor Bioorg Med Chem Lett 6:47-50 (1996)    Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50051884
Synonyms:
1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl]-3,5-dimethyl-1H-pyrazole | CHEMBL33661 | Diphenylimidazole analogue
Type:
Small organic molecule
Emp. Form.:
C25H28N4OS
Mol. Mass.:
432.581
SMILES:
Cc1cc(C)n(CCCCCS(=O)c2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1
Structure:
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