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Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50288786
Substrate
n/a
Meas. Tech.
ChEBML_159295
IC50
23±n/a nM
Citation
 Chen, JJ; Coles, PJ; Arnold, LD; Smith, RA; MacDonald, ID; Carrière, J; Krantz, A Synthesis and activity of conformationally-constrained macrocyclic norstatine-based inhibitors of HIV protease Bioorg Med Chem Lett 6:435-438 (1996)    Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50288786
Synonyms:
(S)-1-((2R,3S)-3-{(S)-3-Carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-2-hydroxy-4-phenyl-butyl)-pyrrolidine-2-carboxylic acid tert-butyl ester | CHEMBL139237
Type:
Small organic molecule
Emp. Form.:
C33H41N5O6
Mol. Mass.:
603.7085
SMILES:
CC(C)(C)OC(=O)[C@@H]1CCCN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1
Structure:
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