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Target
MHC class II antigen
Ligand
BDBM50289247
Substrate
n/a
Meas. Tech.
ChEMBL_192854 (CHEMBL800187)
IC50
5.3±n/a nM
Citation
 Cunningham, BR; Rivetna, M; Tolman, RL; Flattery, SJ; Nichols, EA; Schwartz, CD; Wicker, LS; Hermes, JD; Jones, AB SAR for MHC class II binding tetrapeptides: Correlation with potential binding site Bioorg Med Chem Lett 7:19-24 (1997)    Article 
Target
Name:
MHC class II antigen
Synonyms:
DR-1 | DR1 | HLA class II histocompatibility antigen DRB1-1 | HLA class II histocompatibility antigen, DRB1-1 beta chain | Human leukocyte antigen DR beta chain | MHC class I antigen DRB1*1
Type:
PROTEIN
Mol. Mass.:
29917.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_192854
Residue:
266
Sequence:
MVCLKLPGGSCMTALTVTLMVLSSPLALAGDTRPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAVDTYCRHNYGVGESFTVQRRVEPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS
  
Inhibitor
Name:
BDBM50289247
Synonyms:
(S)-2-((S)-3-Carbamoyl-2-{(S)-2-[((R)-2-ethoxycarbonylamino-3-naphthalen-2-yl-propionyl)-methyl-amino]-5-guanidino-pentanoylamino}-propionylamino)-3-methyl-butyric acid | CHEMBL421516
Type:
Small organic molecule
Emp. Form.:
C32H46N8O8
Mol. Mass.:
670.7564
SMILES:
CCOC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O
Structure:
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