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Target
D(1A) dopamine receptor
Ligand
BDBM50292556
Substrate
n/a
Meas. Tech.
ChEMBL_483725 (CHEMBL997480)
IC50
11100±n/a nM
Citation
 Cortes, D; Figadere, B; Saez, J; Protais, P Displacement Activity of Bisbenzylisoquinoline Alkaloids at Striatal 3H-SCH 23390 and 3H-Raclopride Binding Sites J Nat Prod 55:1281-1286 (1992) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DOPAMINE D1 | DRD1_RAT | Dopamine D1 high | Dopamine D1 low | Dopamine receptor | Dopamine receptor D1 | Dopamine1-like | Drd1 | Drd1a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49429.75
Organism:
RAT
Description:
P18901
Residue:
446
Sequence:
MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
  
Inhibitor
Name:
BDBM50292556
Synonyms:
(S,S)-oxandrine hydrochloride | CHEMBL445011
Type:
Small organic molecule
Emp. Form.:
C37H38N2O7
Mol. Mass.:
622.7068
SMILES:
COc1cc2CCN(C)[C@H]3Cc4ccc(OC)c(c4)-c4cc(ccc4O)C(=O)[C@H]4N(C)CCc5cc(OC)c(Oc(c1O)c23)cc45 |r|
Structure:
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