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Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM50294222
Substrate
n/a
Meas. Tech.
ChEMBL_574908 (CHEMBL1023605)
IC50
4500±n/a nM
Citation
 Kowalska, J; Lukaszewicz, M; Zuberek, J; Ziemniak, M; Darzynkiewicz, E; Jemielity, J Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation. Bioorg Med Chem Lett 19:1921-5 (2009) [PubMed]  Article 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
EIF4E | IF4E_RABIT
Type:
PROTEIN
Mol. Mass.:
25047.40
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_1511842
Residue:
217
Sequence:
MATVEPETTPTPNPPPAEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM50294222
Synonyms:
((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxido-9H-purin-1-ium-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl triphosphate | CHEMBL550695
Type:
Small organic molecule
Emp. Form.:
C11H14N5O14P3
Mol. Mass.:
533.1774
SMILES:
C[n+]1cn(C2OC(COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C(O)C2O)c2nc(N)[n-]c(=O)c12
Structure:
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