Reaction Details Report a problem with these data
Target
Tyrosinase
Ligand
BDBM29612
Substrate
n/a
Meas. Tech.
ChEMBL_579688 (CHEMBL1053202)
Ki
240000±n/a nM
Citation
 Yamazaki, Y; Kawano, Y; Yamanaka, A; Maruyama, S N-[(Dihydroxyphenyl)acyl]serotonins as potent inhibitors of tyrosinase from mouse and human melanoma cells. Bioorg Med Chem Lett 19:4178-82 (2009) [PubMed]  Article 
Target
Name:
Tyrosinase
Synonyms:
TYRO_MOUSE | Tyr
Type:
Protein
Mol. Mass.:
60600.74
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
533
Sequence:
MFLAVLYCLLWSFQISDGHFPRACASSKNLLAKECCPPWMGDGSPCGQLSGRGSCQDILLSSAPSGPQFPFKGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFGGPNCTEKRVLIRRNIFDLSVSEKNKFFSYLTLAKHTISSVYVIPTGTYGQMNNGSTPMFNDINIYDLFVWMHYYVSRDTLLGGSEIWRDIDFAHEAPGFLPWHRLFLLLWEQEIRELTGDENFTVPYWDWRDAENCDICTDEYLGGRHPENPNLLSPASFFSSWQIICSRSEEYNSHQVLCDGTPEGPLLRNPGNHDKAKTPRLPSSADVEFCLSLTQYESGSMDRTANFSFRNTLEGFASPLTGIADPSQSSMHNALHIFMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLLEVYPEANAPIGHNRDSYMVPFIPLYRNGDFFITSKDLGYDYSYLQESDPGFYRNYIEPYLEQASRIWPWLLGAALVGAVIAAALSGLSSRLCLQKKKKKKQPQEERQPLLMDKDDYHSLLYQSHL
  
Inhibitor
Name:
BDBM29612
Synonyms:
CHEMBL33103 | CVD-0001578 | JOH-MSK-a63bdd1d-4 | N-ACETYL SEROTONIN | N-Acetyl-5-hydroxytryptamine | N-Acetyltryptamine,5-Hydroxy | N-acetylserotonin | Normelatonin | Serotonin,N-acetyl
Type:
Small organic molecule
Emp. Form.:
C12H14N2O2
Mol. Mass.:
218.2518
SMILES:
CC(=O)NCCc1c[nH]c2ccc(O)cc12
Structure:
Search PDB for entries with ligand similarity: