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Target
Acid-sensing ion channel 3
Ligand
BDBM50296570
Substrate
n/a
Meas. Tech.
ChEMBL_582093 (CHEMBL1061604)
IC50
59000±n/a nM
Citation
 Kuduk, SD; Chang, RK; Wai, JM; Di Marco, CN; Cofre, V; DiPardo, RM; Cook, SP; Cato, MJ; Jovanovska, A; Urban, MO; Leitl, M; Spencer, RH; Kane, SA; Hartman, GD; Bilodeau, MT Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3). Bioorg Med Chem Lett 19:4059-63 (2009) [PubMed]  Article 
Target
Name:
Acid-sensing ion channel 3
Synonyms:
ACCN3 | ASIC3 | ASIC3_HUMAN | Amiloride-sensitive cation channel 3 | SLNAC1 | TNAC1
Type:
PROTEIN
Mol. Mass.:
58910.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_757561
Residue:
531
Sequence:
MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQVPHLSLGPRPPTPPCAVTKTLSASHRTCYLVTQL
  
Inhibitor
Name:
BDBM50296570
Synonyms:
2-(3-bromo-5-fluorophenyl)-1H-indole-5-carboximidamide | CHEMBL556428
Type:
Small organic molecule
Emp. Form.:
C15H11BrFN3
Mol. Mass.:
332.17
SMILES:
NC(=N)c1ccc2[nH]c(cc2c1)-c1cc(F)cc(Br)c1
Structure:
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