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Target
M-phase inducer phosphatase 2
Ligand
BDBM50297589
Substrate
n/a
Meas. Tech.
ChEMBL_583685 (CHEMBL1061731)
IC50
9500±n/a nM
Citation
 Park, H; Li, M; Choi, J; Cho, H; Ham, SW Structure-based virtual screening approach to identify novel classes of Cdc25B phosphatase inhibitors. Bioorg Med Chem Lett 19:4372-5 (2009) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 2
Synonyms:
CDC25B | CDC25HU2 | Dual specificity phosphatase (CDC25B) | Dual specificity phosphatase Cdc25B | M-phase inducer phosphatase 2 (CDC25B) | MPIP2_HUMAN
Type:
Protein
Mol. Mass.:
64985.27
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
580
Sequence:
MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
  
Inhibitor
Name:
BDBM50297589
Synonyms:
2-chloro-3-(4-fluorophenethylamino)naphthalene-1,4-dione | CHEMBL558268
Type:
Small organic molecule
Emp. Form.:
C18H13ClFNO2
Mol. Mass.:
329.753
SMILES:
Oc1c(Cl)c(N=CCc2ccc(F)cc2)c(O)c2ccccc12 |w:5.4|
Structure:
Search PDB for entries with ligand similarity: