Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM50299526
Substrate
n/a
Meas. Tech.
ChEMBL_591437 (CHEMBL1054557)
IC50
540±n/a nM
Citation
 Dahl, RSergienko, EASu, YMostofi, YSYang, LSimao, AMNarisawa, SBrown, BMangravita-Novo, AVicchiarelli, MSmith, LHO'Neill, WCMillán, JLCosford, ND Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP). J Med Chem 52:6919-25 (2009) [PubMed]  Article 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM50299526
Synonyms:
5-chloro-2-ethoxy-N-(pyridin-3-yl)benzenesulfonamide | CHEMBL565468 | cid_9267841
Type:
Small organic molecule
Emp. Form.:
C13H13ClN2O3S
Mol. Mass.:
312.772
SMILES:
CCOc1ccc(Cl)cc1S(=O)(=O)Nc1cccnc1
Structure:
Search PDB for entries with ligand similarity: