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Target
Phospholipase A-2-activating protein
Ligand
BDBM50299523
Substrate
n/a
Meas. Tech.
ChEMBL_591442 (CHEMBL1054562)
IC50
>100000±n/a nM
Citation
 Dahl, R; Sergienko, EA; Su, Y; Mostofi, YS; Yang, L; Simao, AM; Narisawa, S; Brown, B; Mangravita-Novo, A; Vicchiarelli, M; Smith, LH; O'Neill, WC; Millán, JL; Cosford, ND Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP). J Med Chem 52:6919-25 (2009) [PubMed]  Article 
Target
Name:
Phospholipase A-2-activating protein
Synonyms:
PLAA | PLAP | PLAP_HUMAN
Type:
PROTEIN
Mol. Mass.:
87154.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_610122
Residue:
795
Sequence:
MTSGATRYRLSCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQITGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVFTESEDRTASAEEIKAFEKELSHATIDSKTGDLGDINAEQLPGREHLNEPGTREGQTRLIRDGEKVEAYQWSVSEGRWIKIGDVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNTSDDPWLTAYNFLQKNDLNPMFLDQVAKFIIDNTKGQMLGLGNPSFSDPFTGGGRYVPGSSGSSNTLPTADPFTGAGRYVPGSASMGTTMAGVDPFTGNSAYRSAASKTMNIYFPKKEAVTFDQANPTQILGKLKELNGTAPEEKKLTEDDLILLEKILSLICNSSSEKPTVQQLQILWKAINCPEDIVFPALDILRLSIKHPSVNENFCNEKEGAQFSSHLINLLNPKGKPANQLLALRTFCNCFVGQAGQKLMMSQRESLMSHAIELKSGSNKNIHIALATLALNYSVCFHKDHNIEGKAQCLSLISTILEVVQDLEATFRLLVALGTLISDDSNAVQLAKSLGVDSQIKKYSSVSEPAKVSECCRFILNLL
  
Inhibitor
Name:
BDBM50299523
Synonyms:
2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide | CHEMBL567850 | cid_2931238
Type:
Small organic molecule
Emp. Form.:
C17H16N2O4S
Mol. Mass.:
344.385
SMILES:
COc1ccc(OC)c(c1)S(=O)(=O)Nc1cnc2ccccc2c1
Structure:
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