Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM50299523
Substrate
n/a
Meas. Tech.
ChEMBL_591449 (CHEMBL1054569)
IC50
240±n/a nM
Citation
 Dahl, RSergienko, EASu, YMostofi, YSYang, LSimao, AMNarisawa, SBrown, BMangravita-Novo, AVicchiarelli, MSmith, LHO'Neill, WCMillán, JLCosford, ND Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP). J Med Chem 52:6919-25 (2009) [PubMed]  Article 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM50299523
Synonyms:
2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide | CHEMBL567850 | cid_2931238
Type:
Small organic molecule
Emp. Form.:
C17H16N2O4S
Mol. Mass.:
344.385
SMILES:
COc1ccc(OC)c(c1)S(=O)(=O)Nc1cnc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: