Target
LIM domain kinase 2
Ligand
BDBM50299595
Substrate
n/a
Meas. Tech.
ChEMBL_592392 (CHEMBL1036965)
IC50
92±n/a nM
Citation
 Harrison, BAWhitlock, NAVoronkov, MVAlmstead, ZYGu, KJMabon, RGardyan, MHamman, BDAllen, JGopinathan, SMcKnight, BCrist, MZhang, YLiu, YCourtney, LFKey, BZhou, JPatel, NYates, PWLiu, QWilson, AGKimball, SDCrosson, CERice, DSRawlins, DB Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma. J Med Chem 52:6515-8 (2009) [PubMed]  Article 
Target
Name:
LIM domain kinase 2
Synonyms:
LIMK2 | LIMK2_HUMAN
Type:
PROTEIN
Mol. Mass.:
72238.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1514398
Residue:
638
Sequence:
MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP
  
Inhibitor
Name:
BDBM50299595
Synonyms:
4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-m-tolylpiperazine-1-carboxamide | CHEMBL571715
Type:
Small organic molecule
Emp. Form.:
C19H22N6O
Mol. Mass.:
350.4176
SMILES:
Cc1c[nH]c2ncnc(N3CCN(CC3)C(=O)Nc3cccc(C)c3)c12
Structure:
Search PDB for entries with ligand similarity: