Target
Cellular tumor antigen p53
Ligand
BDBM50025671
Substrate
n/a
Meas. Tech.
ChEMBL_589609 (CHEMBL1052162)
IC50
3000±n/a nM
Citation
 Allen, JGBourbeau, MPWohlhieter, GEBartberger, MDMichelsen, KHungate, RGadwood, RCGaston, RDEvans, BMann, LWMatison, MESchneider, SHuang, XYu, DAndrews, PSReichelt, ALong, AMYakowec, PYang, EYLee, TAOliner, JD Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. J Med Chem 52:7044-53 (2009) [PubMed]  Article 
Target
Name:
Cellular tumor antigen p53
Synonyms:
Antigen NY-CO-13 | CREB-binding protein/p53 | GST-p53 | His6-p53 | P53 | P53_HUMAN | Phosphoprotein p53 | TP53 | Tumor Suppressor p53
Type:
fusion protein
Mol. Mass.:
43654.73
Organism:
Homo sapiens (Human)
Description:
The full-length His6-wt-p53 expressed in E. coli was used in assays.
Residue:
393
Sequence:
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
  
Inhibitor
Name:
BDBM50025671
Synonyms:
CHEMBL583413
Type:
Small organic molecule
Emp. Form.:
C26H20Br2N4O
Mol. Mass.:
564.271
SMILES:
CN1c2ncnn2C(C2=C1c1cc(C)ccc1OC2c1ccc(Br)cc1)c1ccc(Br)cc1 |c:9|
Structure:
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