Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50300290
Substrate
n/a
Meas. Tech.
ChEMBL_590638 (CHEMBL1052922)
Ki
2.4±n/a nM
Citation
 Tosh, DK; Chinn, M; Ivanov, AA; Klutz, AM; Gao, ZG; Jacobson, KA Functionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system. J Med Chem 52:7580-92 (2009) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50300290
Synonyms:
(1R,2R,3S,4R,5S)-2,3-dihydroxy-4-(6-(3-iodobenzylamino)-9H-purin-9-yl)-N-methylbicyclo[3.1.0]hexane-1-carboxamide | CHEMBL583637
Type:
Small organic molecule
Emp. Form.:
C20H21IN6O3
Mol. Mass.:
520.3236
SMILES:
CNC(=O)[C@]12C[C@@H]1[C@H]([C@H](O)[C@@H]2O)n1cnc2c(NCc3cccc(I)c3)ncnc12 |r|
Structure:
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