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Target
Synaptic vesicular amine transporter
Ligand
BDBM50301022
Substrate
n/a
Meas. Tech.
ChEMBL_598160 (CHEMBL1044344)
Ki
0.1±n/a nM
Citation
 Zhu, L; Liu, J; Kung, HF Synthesis and evaluation of 2-amino-dihydrotetrabenzine derivatives as probes for imaging vesicular monoamine transporter-2. Bioorg Med Chem Lett 19:5026-8 (2009) [PubMed]  Article 
Target
Name:
Synaptic vesicular amine transporter
Synonyms:
Monoamine transporter | SLC18A2 | SVMT | Solute carrier family 18 member 2 | VAT2 | VMAT2 | VMAT2_HUMAN | Vesicular amine transporter 2
Type:
PROTEIN
Mol. Mass.:
55709.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_610810
Residue:
514
Sequence:
MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEIQTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD
  
Inhibitor
Name:
BDBM50301022
Synonyms:
(+)-9-fluoropropyl-dihydrotetrabenazine | CHEMBL579217
Type:
Small organic molecule
Emp. Form.:
C21H32FNO3
Mol. Mass.:
365.4821
SMILES:
COc1cc2[C@H]3C[C@@H](O)[C@H](CC(C)C)CN3CCc2cc1OCCCF |r|
Structure:
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