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TargetUTS2R
LigandBDBM50302228
Substrate/Competitorn/a
Meas. Tech.ChEMBL_596665
IC50 84±n/a nM
Citation Lawson, ECLuci, DKGhosh, SKinney, WAReynolds, CHQi, JSmith, CEWang, YMinor, LKHaertlein, BJParry, TJDamiano, BPMaryanoff, BE Nonpeptide urotensin-II receptor antagonists: a new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits. J Med Chem52:7432-45 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
UTS2R
Name:UTS2R
Synonyms:G-protein coupled receptor 14 | G-protein coupled sensory epithelial neuropeptide-like receptor | SENR | UR-II-R | Urotensin-II
Type:Enzyme Catalytic Domain
Mol. Mass.:42725.34
Organism:RAT
Description:Urotensin-II UTS2R RAT::P49684
Residue:386
Sequence:
MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSA
MGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGD
VGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLL
TLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWL
SQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNY
LTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSG
RSLSSSSQQATETLMLSPVPRNGALL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50302228
NameBDBM50302228
Synonyms:(R)-2-(3,4-dimethoxybenzyl)-4-(4-(1-phenylethyl)piperazin-1-yl)isoindoline-1,3-dione | CHEMBL572138 | JNJ-28318706
TypeSmall organic molecule
Emp. Form.C29H31N3O4
Mol. Mass.485.5741
SMILESCOc1ccc(CN2C(=O)c3cccc(N4CCN(CC4)[C@H](C)c4ccccc4)c3C2=O)cc1OC |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a