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TargetUrotensin II receptor
LigandBDBM50302249
Substrate/Competitorn/a
Meas. Tech.ChEMBL_596667
IC50 150±n/a nM
Citation Lawson, ECLuci, DKGhosh, SKinney, WAReynolds, CHQi, JSmith, CEWang, YMinor, LKHaertlein, BJParry, TJDamiano, BPMaryanoff, BE Nonpeptide urotensin-II receptor antagonists: a new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits. J Med Chem52:7432-45 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Urotensin II receptor
Name:Urotensin II receptor
Synonyms:G-protein coupled receptor 14 | UR-II-R | Urotensin-II
Type:Enzyme Catalytic Domain
Mol. Mass.:42159.71
Organism:Homo sapiens (Human)
Description:Urotensin-II UTS2R HUMAN::Q9UKP6
Residue:389
Sequence:
MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSA
MGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGD
VGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLL
TLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRR
SQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLT
TCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLS
SCSPQPTDSLVLAPAAPARPAPEGPRAPA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50302249
NameBDBM50302249
Synonyms:(R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)-1,3-dioxoisoindolin-2-yl)butyl)thiophene-2-sulfonamide | CHEMBL566433
TypeSmall organic molecule
Emp. Form.C30H36N4O6S2
Mol. Mass.612.76
SMILESCCN1CCN(CC1)c1cccc2C(=O)N([C@H](CCCNS(=O)(=O)c3cccs3)c3ccc(OC)c(OC)c3)C(=O)c12 |r|
Structure
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n/a